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3D Printed Endometrial Carcinoma
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U.S. Contiguous States Only
by Erler Zimmer Monash University
A trusted GT partner
3D Printed Model
from a real specimen
Available upon request
3D Printed Endometrial Carcinoma
A 63-year old woman presented with a history of dull lower abdominal pain for 2 months and heavy persistent vaginal bleeding for 1 week. The menopause had occurred 13 years previously. Radical abdominal hysterectomy and bilateral salpingo-oophorectomy were commonly performed for the treatment of endometrial cancer following confirmation of endometrial carcinoma in biopsy.
The specimen consists of uterus, fallopian tubes and ovaries. The endometrial cavity and endocervical canal have been opened on the anterior aspect. The endometrial lining is grossly abnormal especially on the right side and a brown polypoid tumour has invaded the myometrium and extends inferiorly into the cervical canal. Histologically this was a well-differentiated adenocarcinoma of the endometrium. The left ovary, which has been sectioned in the coronal plane, is enlarged and has several large follicular cysts/cavities.
Endometrial carcinoma is the most common gynecological malignancy in developed countries and the second most common in developing countries after cervical cancer. There are two major types of endometrial carcinoma. Endometroid carcinoma account for almost 80% of endometrial carcinoma. They usually present early and so have a more favourable outcome. These tumours may arise from atypical endometrial hyperplasia. Common genetic abnormalities seen in endometrioid tumours are mutations in the PTEN, PIK3Ca and ARID1A genes. Serous carcinoma are a less common form of endometrial carcinoma. These tumours are associated with mutations in TP53 gene and carry a poorer prognosis. Endometrioid tumours tend to affect women aged 55 to 65 years. Risk factors for developing endometrioid endometrial cancer include obesity, impaired glucose tolerance, infertility, unopposed estrogen therapy (e.g. early menarche, late menopause or exogenous sources). Serous neoplasms affect older women aged 65 to 75 years with other risk factors for development include having a lower BMI and an atrophic uterus. Women with Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) have a significantly higher risk of developing endometrial cancer.
The most common symptom of endometrial cancer is abnormal vaginal bleeding. Most frequently it presents as post-menopausal bleeding, which often allows early presentation. Others may be asymptomatic or an incidental finding of an abnormal endometrium on abdominopelvic imaging. The main radiological sign of endometrial cancer is abnormally thickened endometrium on pelvic ultrasound or CT scan. Diagnosis is made on endometrial biopsy, endometrial curettage or hysterectomy. Treatment depends on the stage of the cancer and includes local radiotherapy, systemic chemotherapy and surgical hysterectomy +/- salpingo-oophorectomy.Download:
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The models are very detailed and delicate. With normal production machines you cannot realize such details like shown in these models.
The printer used is a color-plastic printer. This is the most suitable printer for these models.
The plastic material is already the best and most suitable material for these prints. (The other option would be a kind of gypsum, but this is way more fragile. You even cannot get them out of the printer without breaking them).The huge advantage of the prints is that they are very realistic as the data is coming from real human specimen. Nothing is shaped or stylized.
The users have to handle these prints with utmost care. They are not made for touching or bending any thin nerves, arteries, vessels etc. The 3D printed models should sit on a table and just rotated at the table.