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3D Printed Astrocytoma
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by Erler Zimmer Monash University
A trusted GT partner
3D Printed Model
from a real specimen
3D Printed Astrocytoma
A 73-year-old female was admitted with new left-sided hemiplegia. On further questioning she revealed a 3-month history of headaches, nausea and deteriorating balance. CT brain revealed an inoperable brain tumour. She died 1 week after being admitted.
This brain specimen is a coronal section. In the right temporal lobe, a poorly demarcated tumour is present. There is enlargement of the hemispheres and flattening of the gyral pattern. From the posterior aspect of the specimen subfalcine herniation* is appreciated and the tumour appear less well differentiated with haemorrhagic and necrotic foci. Histology of this tumour showed an astrocytoma, Grade III/IV.
*In subfalcine (or cingulate) herniation, the most common type of brain herniation, the innermost part of the frontal lobe is pushed under part of the falx cerebri, between the two hemispheres of the brain.
Gliomas are the second most common cancer of the central nervous system after meningiomas. The term “glioma” refers to tumours that are histologically similar to normal glial cells i.e. astrocytes, oligodendrocytes and ependymal cells. They arise from a progenitor cell that differentiates down one of the cell lines. Astrocytomas develop from the astrocyte lineage of glial cells. Tumours are staged according to histological differentiation and range from diffuse astrocytoma (Grade II/IV) to anaplastic astrocytoma (Grade III/IV) to glioblastoma (Grade IV). Histological features include the prominent eosinophilic cytoplasm in some astrocytic tumour cells (gemistocytes) as well as a fibrillary background.
Astrocytomas occur most commonly between the fourth and sixth decades of life. Tumours usually occur in the cerebral hemispheres but may also occur in the cerebellum, brainstem or spinal cord. They most commonly present with seizures, headaches, nausea and focal neurological deficits depending on area involved. Without treatment Grade III median survival is 18 months. Treatment includes surgical resection, radiotherapy, chemotherapy or a combination thereof, depending on the clinical context.
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The models are very detailed and delicate. With normal production machines you cannot realize such details like shown in these models.
The printer used is a color-plastic printer. This is the most suitable printer for these models.
The plastic material is already the best and most suitable material for these prints. (The other option would be a kind of gypsum, but this is way more fragile. You even cannot get them out of the printer without breaking them).The huge advantage of the prints is that they are very realistic as the data is coming from real human specimen. Nothing is shaped or stylized.
The users have to handle these prints with utmost care. They are not made for touching or bending any thin nerves, arteries, vessels etc. The 3D printed models should sit on a table and just rotated at the table.